解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Selection of patients with local failure of nasopharyngeal carcinoma (NPC) for appropriate type of salvage treatment can be difficult due to the lack of data on comparative efficacy of different salvage treatments. The purpose of the present study was to validate a previously published prognostic scoring sys...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-131
更新日期:2009-04-29 00:00:00
abstract:BACKGROUND:Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbidity on treatment choice. This study aimed to assess the impact of comorbidity on colon cancer patien...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-116
更新日期:2009-04-20 00:00:00
abstract:BACKGROUND:One of the basic prerequisites for generating evidence-based data is the availability of classification systems. Attempts to date to classify breast cancer operations have focussed on specific problems, e.g. the avoidance of secondary corrective surgery for surgical defects, rather than taking a generic appr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-108
更新日期:2009-04-08 00:00:00
abstract:BACKGROUND:During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening with mammography played a role in the decline in mortality. Evaluating the contribution of these int...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-98
更新日期:2009-03-30 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether radiation (RT)-induced inflammatory responses and organ damage might be modulated by androgen deprivation therapies. METHODS:The mRNA and tissue sections obtained from the lungs, intestines and livers of irradiated mice with or without androgen deprivation were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-92
更新日期:2009-03-25 00:00:00
abstract:BACKGROUND:Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-85
更新日期:2009-03-17 00:00:00
abstract:BACKGROUND:Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. METHODS:To compare the functional role of E-cadherin and P-cadherin in inva...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-74
更新日期:2009-03-03 00:00:00
abstract:BACKGROUND:Cervical cancer is the most common malignant gynecological cancer, and lymphatic metastasis can occur in the early stage of tumor growth. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a marker for lymphatic endothelium, provides powerful tools for studying tumor lymphangiogenesis. The purpose ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-64
更新日期:2009-02-21 00:00:00
abstract:BACKGROUND:The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis in vitro. In this study, the mechanism of action of ARC was further investigated by comparing in vitro and in vivo activity with other ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-63
更新日期:2009-02-20 00:00:00
abstract:BACKGROUND:The molecular mechanisms of the development and progression of bladder cancer are poorly understood. The objective of this study was to analyze the expression of Bmi-1 protein and its clinical significance in human bladder cancer. METHODS:We examined the expression of Bmi-1 mRNA and Bmi-1 protein by RT-PCR ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-61
更新日期:2009-02-19 00:00:00
abstract:BACKGROUND:The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblasto...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-57
更新日期:2009-02-17 00:00:00
abstract:BACKGROUND:Clinical characterization of bladder carcinomas is still inadequate using the standard clinico-pathological prognostic markers. We assessed the correlation between nm23-H1, Rb, EGFR and p53 in relation to the clinical outcome of patients with muscle invasive bilharzial bladder cancer (MI-BBC). METHODS:nm23-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-32
更新日期:2009-01-26 00:00:00
abstract:BACKGROUND:Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, proliferation, invasiveness, and angiogenesis. METHOD:To understand how FAK affects oncogenesis throu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-12
更新日期:2009-01-12 00:00:00
abstract:BACKGROUND:Accurate assessment of HER-2/neu status is crucial for proper prognostic information and to offer direct appropriate treatment for breast cancer patients. Next to immunohistochemistry (IHC) to evaluate HER2 protein overexpression, a second line gene amplification test is generally deemed necessary for cases ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-4
更新日期:2009-01-05 00:00:00
abstract:BACKGROUND:SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, yet data about their collective behavior in hepatocellular carcinoma (HCC) is missing. Hence, we qua...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-392
更新日期:2008-12-29 00:00:00
abstract:BACKGROUND:Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are characterized by an asynchronous mode of replication (well exemplified by the SNRPN imprinted locus...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-390
更新日期:2008-12-25 00:00:00
abstract:BACKGROUND:Kidney and renal pelvis cancers account for 4% of all new cancer cases in the United States, among which 85% are renal cell carcinomas (RCC). While cigarette smoking is an established risk factor for RCC, little is known about the contribution of environmental tobacco smoke (ETS) to RCC incidence. This study...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-387
更新日期:2008-12-24 00:00:00
abstract:BACKGROUND:Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-382
更新日期:2008-12-19 00:00:00
abstract:BACKGROUND:Cell lines are often poorly characterized from a genetic point of view, reducing their usefulness as tumor models. Our purpose was to assess the genetic background of eight commonly used human thyroid carcinoma models and to compare the findings with those reported for primary tumors of the gland. METHODS:W...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-8-371
更新日期:2008-12-16 00:00:00
abstract:BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-365
更新日期:2008-12-11 00:00:00
abstract:BACKGROUND:Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17beta-estradiol. These findings suggest that E6 performs critical functions in normal adult cervix and skin, highli...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-347
更新日期:2008-11-26 00:00:00
abstract:BACKGROUND:The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are therefore viewed as attractive drug candidates for the targeted therapy of this malignancy. However, the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-337
更新日期:2008-11-17 00:00:00
abstract:BACKGROUND:Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as anti-tumor activity. The aim of the present work was to study the growth inhibition of tumor cells by butanol extract of Bifidobac...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-310
更新日期:2008-10-27 00:00:00
abstract:BACKGROUND:Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a subset of breast cancer with different biologic behaviour. We investigated the clinicopathologic charac...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-307
更新日期:2008-10-23 00:00:00
abstract:BACKGROUND:Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-297
更新日期:2008-10-14 00:00:00
abstract:BACKGROUND:Since the second half of the 1990s, kidney cancer mortality has tended to stabilize and decline in many European countries, due to the decrease in the prevalence of smokers. Nevertheless, incidence of kidney cancer is rising across the sexes in some of these countries, a trend which may possibly reflect the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-293
更新日期:2008-10-09 00:00:00
abstract:BACKGROUND:Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer. METHODS:To further understand Herceptin resistance mechanisms at the molecular level, we used comparative proteome approaches to analyze two human ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-286
更新日期:2008-10-04 00:00:00
abstract:INTRODUCTION:A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investigated additional MDM2 intron 1 polymorphisms. METHODS:Intron 1 of MDM2 was PCR amplified and direct...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-281
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:There is no biological or epidemiological data on the association between NOS3 promoter polymorphisms and prostate cancer. The polymorphisms in the promoter region of NOS3 gene may be responsible for variations in the plasma NO, which may promote cancer progression by providing a selective growth advantage t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-273
更新日期:2008-09-29 00:00:00
abstract:BACKGROUND:In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. The aim of this study is to identify and rank the risk factors of muscle invasive bladder cancer (M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-250
更新日期:2008-08-29 00:00:00
abstract:BACKGROUND:Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS:LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-235
更新日期:2008-08-13 00:00:00
abstract:BACKGROUND:Tetratricopeptide repeat domain 9A (TTC9A) protein is a recently identified protein which contains three tetratricopeptide repeats (TPRs) on its C-terminus. In our previous studies, we have shown that TTC9A was a hormonally-regulated gene in breast cancer cells. In this study, we found that TTC9A was over-ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-231
更新日期:2008-08-12 00:00:00
abstract:BACKGROUND:Primary central nervous system lymphoma (PCNSL) is a frequent complication in acquired immunodeficiency syndrome (AIDS). The objective of this survey was to investigate incidence, clinical features, radiological findings, histologic diagnosis, treatment and outcome for all patients with histologically verifi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-225
更新日期:2008-08-06 00:00:00
abstract:BACKGROUND:Genome-wide changes in DNA methylation are an epigenetic phenomenon that can lead to the development of disease. The study of global DNA methylation utilizes technology that requires both expensive equipment and highly specialized skill sets. METHODS:We have designed and developed an assay, CpGlobal, which ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-222
更新日期:2008-08-03 00:00:00
abstract:BACKGROUND:The main objective of this study was to evaluate the safety of second-line pemetrexed in Stage IIIB or IV NSCLC. METHODS:Overall, 95 patients received pemetrexed 500 mg/m2 i.v. over Day 1 of a 21-day cycle. Patients also received oral dexamethasone, oral folic acid and i.m. vitamin B12 supplementation to re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-216
更新日期:2008-07-31 00:00:00
abstract:BACKGROUND:In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ). METH...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-211
更新日期:2008-07-25 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1alpha and STAT3 have been implicated in HCC progression, thus representing interesting targets for molecu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-206
更新日期:2008-07-23 00:00:00
abstract:BACKGROUND:Classical in vitro wound-healing assays and other techniques designed to study cell migration and invasion have been used for many years to elucidate the various mechanisms associated with metastasis. However, many of these methods are limited in their ability to achieve reproducible, quantitative results th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-198
更新日期:2008-07-14 00:00:00
abstract:BACKGROUND:Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas. METHODS:Plasmids containing either MMP-2 siRNA or tissue inhibitor of metalloproteinase-2 (TIMP-2) cDNA were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-182
更新日期:2008-06-30 00:00:00
abstract:BACKGROUND:The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC). METHODS:Samples of cancerous and non-cancerous liver tissue were taken from 40 patients with HCC who underwent hepatectomy. Expression of hepcidin mRNA was evaluated by real-time PCR, and compared in tumors differ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-167
更新日期:2008-06-09 00:00:00